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Cirillo, Pier (full)
Pier
Cirillo
Ph.D.
Lecturer
Tagliatela College of Engineering
Chemistry & Chemical Engineering
203-479-4887
BCKM303
Buckman Hall
Biography

    Recent Professional Activities

    Medicinal Chemistry Consultant – L2 Diagnostics, since 2011

    Principal Scientist – Boehringer Ingelheim Pharmaceuticals, Inc.  2003-2008

    Senior Scientist – Boehringer Ingelheim Pharmaceuticals, Inc.  1997-2002

    Post-Doctoral Research Fellow – Memorial Sloan-Kettering Cancer Center  1995-1996

    Doctoral Dissertation

    Chiral Allylic Silanes in Organic Synthesis: Formal Synthesis of (+)-Sesbanimide A.  Doctorate in Philosophy. Boston University, 1995
Academic Credentials

    Education

    Ph.D. in Synthetic Organic Chemistry, Boston University, 1995 
    B.Sc. Hons. in Chemistry, University of the Witwatersrand, 1987

    Issued US Patents

    US  7,928,123  Compounds which modulate the CB2 receptor. Issued Apr 19, 2011
    US  7,935,715  Compounds which modulate the CB2 receptor. Issued May 03, 2011 
    US  6,080,763  Aromatic heterocyclic compounds and their use as anti-inflammatory agents. Issued Jun 27, 2000
    US  6,228,881  Aromatic heterocyclic compounds and their use as anti-inflammatory agents. Issued May 08, 2001 
    US  6,319,921  Aromatic heterocyclic compound as antiinflammatory agents. Issued Nov 20, 2001  
    US  6,242,453  Polycyclo heterocyclic derivatives as antiinflammatory agents. Issued Jun 05, 2001  
    US  6,297,381  Aromatic heterocyclic compounds as anti-inflammatory agents. Issued Oct 02, 2001 
    US  6,358,945  Compounds useful as anti-inflammatory agents. Issued Mar 19, 2002  
    US  6,492,393  Compounds useful as anti-inflammatory agents.  Issued Dec 10, 2002  
    US  6,476,023  Aromatic heterocyclic compounds as anti-inflammatory agents. Issued Nov 05, 2002 
    US  6,608,052  Compounds useful as anti-inflammatory agents Issued Aug 19, 2003 
    US  6,333,325  Method of treating cytokine mediated diseases or conditions. Issued Dec 25, 2001  
    US  6,329,415  Aromatic heterocyclic compounds as antiinflammatory agents. Issued Dec 11, 2001  
    US  6,660,732  Compounds useful as anti-inflammatory agents. Issued Dec 09, 2003 
    US  7,026,476  Intermediate arylamine compounds. Issued Apr 11, 2006  
    US  7,019,006  Compounds useful as anti-inflammatory agents. Issued Mar 28, 2006.

    Selected Scholarly Publications

    Cirillo, Pier F.; Hickey, Eugene; Breitfelder, Steffen; Betageri, Raj; Fadra, Tazmeen; Gaenzler, Faith; Gilmore, Thomas; Goldberg, Daniel; Kamhi, Victor; Kirrane, Thomas; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Netherton, Matthew; Pargellis, Christopher A.; Patel, Usha; Qian, Kevin C.; Regan, John R.; Sharma, Rajiv; Sun, Sanxing; Swinamer, Alan; Torcellini, Carol; Takahashi, Hidenori; Tsang, Michele, Xiong, Zhaoming; Moss, Neil Discovery and Characterization of the N-Phenyl-N’-Naphthylurea Class of p38 MAP Kinase Inhibitors. Bioorganic and Medicinal Chemistry Letters (2009), 19(9), 2386-2391.

    Regan, John; Capolino, Alison; Cirillo, Pier F.; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Nelson, Richard; Pargellis, Christopher A.; Swinamer, Alan; Torcellini, Carol; Tsang, Michele; Moss, Neil.  Structure-Activity Relationships of the p38a MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB 796).    Journal of Medicinal Chemistry (2003), 46(22), 4676-4686.

    Cirillo, Pier F.; Pargellis, Christopher; Regan, John. The non-diaryl heterocycle classes of p38 MAP kinase inhibitors. Current Topics in Medicinal Chemistry (Hilversum, Netherlands) (2002), 2(9), 1021-1035.

    Regan, John; Breitfelder, Steffen; Cirillo, Pier; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Klaus, Bernhard; Madwed, Jeffrey; Moriak, Monica; Moss, Neil; Pargellis, Chris; Pav, Sue; Proto, Alfred; Swinamer, Alan; Tong, Liang; Torcellini, Carol.  Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate. Journal of Medicinal Chemistry (2002), 45(14), 2994-3008.

    Pargellis, Christopher; Tong, Liang; Churchill, Laurie; Cirillo, Pier F.; Gilmore, Thomas; Graham, Anne G.; Grob, Peter M.; Hickey, Eugene R.; Moss, Neil; Pav, Susan; Regan, John.  Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Structural Biology (2002), 9(4), 268-272.

    Cirillo, Pier F.; Danishefsky, Samuel J.  The glycal assembly method on solid supports: synthesis of oligosaccharides and glycoconjugates.  Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries (2001), 15-40. P.H. Seeberger Ed., Wiley, New York.

    Danishefsky, Samuel J.; Hu, Shuanghua; Cirillo, Pier F.; Eckhardt, Matthias; Seeberger, Peter H.  A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif.   Chemistry-A European Journal (1997), 3(10), 1617-1628.

    Seeberger, Peter H.; Cirillo, Pier F.; Hu, Shuanghua; Beebe, Xenia; Bilodeau, Mark T.; Danishefsky, Samuel J.  Synthesis of the pentasaccharide core structure of asparagine-linked glycoprotein oligosaccharides by the glycal assembly method. Enantiomer (1996), 1(4-6), 311-323.

    Jain, Nareshkumar F.; Cirillo, Pier F.; Pelletier, Roberta; Panek, James S.  Double stereodifferentiation in the Lewis acid promoted crotylation of (S)-2-alkoxypropanal with chiral b-alkyl (E)-crotylsilanes. Tetrahedron Letters (1995), 36(48), 8727-30.

    Cirillo, Pier F.; Panek, James S.  Studies directed toward the synthesis of (+)-sesbanimide A: construction of the AB-ring system (a formal total synthesis). Journal of Organic Chemistry (1994), 59(11), 3055-63.

    Panek, James S.; Cirillo, Pier F.  Acyclic diastereoselectivity in the Lewis acid promoted additions of chiral, b-methyl-substituted (E)-crotylsilanes with achiral aldehydes. Journal of Organic Chemistry (1993), 58(5), 999-1002. Cirillo, Pier F.; Panek, James S.  Recent progress in the chemistry of acylsilanes.  A review. Organic Preparations and Procedures International (1992), 24(5), 553-82.

    Cirillo, Pier F.; Panek, James S.  Diastereoselectivity in nucleophilic addition reactions to(a,b-dialkoxyacyl) silanes:  an operationally useful route to optically active 1,2,3-syn-triols. Journal of Organic Chemistry (1990), 55(25), 6071-3.

    Panek, James S.; Cirillo, Pier F. p-Facial selectivity in catalytic osmylation reactions of chiral C1-oxygenated allylic silanes.  Journal of the American Chemical Society (1990), 112(12), 4873-8.

    Courses Taught

    • CH 501 Advanced Organic Chemistry
    • CH 201 Organic Chemistry I with Lab
    • CH 115 General Chemistry with Lab
    • CH 105 Laboratory